Combined Factor V and Factor VIII Deficiency

Combined factor V (FV) and factor VIII (FVIII) deficiency is a very rare inherited bleeding disorder. It is completely separate from factor V deficiency and FVIII deficiency. Factor V and factor VIII are proteins in the blood which help blood clot. In this disorder, levels of both factors are much lower than normal. It is more common in communities where there are often marriages between close relatives and most cases are found around the Mediterranean Sea, especially in Israel, Iran, and Italy.

Links to selected resources:

What Is Combined Factor V and Factor VIII Deficiency?
(World Federation of Hemophilia)
See the About Bleeding Disorders section. Explains the causes of this blood disorder, its symptoms, diagnosis and treatment.

Combined factor V and factor VIII deficiency
(Canadian Hemophilia Society)
This booklet explains what combined factor V and factor VIII deficiency is, how common it is, how it is passed on, symptoms, diagnosis and treatment.

Source: What are rare clotting factor deficiencies? World Federation of Hemophilia, Montreal, Canada, 2009.

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Date last reviewed: 13th November 2015