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Combined Factor V and Factor VIII Deficiency

Combined factor V (5) and factor VIII (8) deficiency is a very rare inherited bleeding disorder. It is completely separate from factor V deficiency and factor VIII  deficiency. Factor V (FV) and factor VIII (FVIII) are proteins in the blood which help blood clot. In this disorder, levels of both factors are much lower than normal. Usually both parents must carry the gene alteration causing the disorder to pass it on to their child and for their child to have the disorder.

Links to selected resources:

What Is Combined Factor V and Factor VIII Deficiency?
(World Federation of Hemophilia)
Explains the causes of this blood disorder, its symptoms, diagnosis and treatment.

Combined factor V and factor VIII deficiency
(Canadian Hemophilia Society)
Explains what combined factor V and factor VIII deficiency is, how common it is, how it is passed on, symptoms, diagnosis and treatment.

Source: What are rare clotting factor deficiencies? World Federation of Hemophilia, Montreal, Canada, 2023.

NB We provide these links as a service to the haemophilia community. As web sites can change or should you find a site to be no longer active please notify [email protected]. Haemophilia Foundation Australia is not responsible for the content of any external web sites. The featuring of a site on this page is not an endorsement by HFA of the information or views expressed therein.

Date last reviewed: 1 February 2024

Important Note: This information was developed by Haemophilia Foundation Australia for education and information purposes only and does not replace advice from a treating health professional. Always see your health care provider for assessment and advice about your individual health before taking action or relying on published information. This information may be printed or photocopied for educational purposes.

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